Relieving the symptoms of oestrogen deficiency (eg hot flushes, decreased sex drive, depression) in women who have gone through the menopause.Prevention of osteoporosis in women who have gone through the menopause and are at high risk of fractures, but cannot take other medicines used to prevent osteoporosis.

Close family history of breast cancer (eg mother, sister or grandmother has had the disease)History of benign breast lumps (fibrocystic breast disease) History of fibroids in the womb History of endometriosis History of overgrowth of the lining of the womb (endometrial hyperplasia) Personal or family history of blood clots in the veins (venous thromboembolism, eg deep vein thrombosis or pulmonary embolism)Blood disorders that increase the risk of blood clots in the veins, eg antiphospholipid syndrome, factor V Leiden Women taking medicines to prevent blood clots (anticoagulants), eg warfarinLong-term inflammation of skin and some internal organs (systemic lupus erythematosus) Personal or family history of recurrent miscarriage Severe obesity Varicose veins SmokersHistory of high blood pressure (hypertension) Raised levels of fats called triglycerides in the blood (hypertriglyceridaemia) History of liver disease, eg liver cancer Decreased kidney functionHeart failure History of diabetes History of gallstones History of migraines or severe headaches History of epilepsy History of asthma History of an ear disorder that may cause hearing loss (otosclerosis) History of irregular brown patches appearing on the skin, usually of the face, during pregnancy or previous use of hormone preparations such as contraceptive pills (chloasma). Women with a tendency to this condition should minimise their exposure to the sun or UV light while taking HRT.Not to be used in Pregnancy 

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.This medicine should not be used by women who are pregnant or breastfeeding. You should stop taking this medicine and consult your doctor immediately if you get pregnant during treatment. A woman is considered fertile for two years after her last menstrual period if she is under 50, or for one year if over 50. HRT does not provide contraception for women who fall within this group. If you could get pregnant while taking this HRT, you should use a non-hormonal method of contraception (eg condoms or contraceptive foam). Seek medical advice from your doctor. 

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here,it does not mean that all people using this medicine will experience that or any side effect.Vaginal bleeding or spottingVaginal dischargeVaginal thrushVaginal itchingBreast painDisturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal painRash or itchingSeborrhoeic dermatitisAbnormal hair growth (hypertrichosis)DizzinessHeadache/migraineWeight gainVisual disturbances such as blurred visionExcessive fluid retention in the body tissues, resulting in swelling (oedema)Pain in the muscles and jointsDepressionAlteration in results of liver function testsIrregular brown patches on the skin, usually of the face (chloasma) Blood clots in the blood vessels (eg, DVT, pulmonary embolism, heart attack, stroke - see warnings above) The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe. The following medicines may potentially reduce the blood levels and effect of this medicine, which could result in recurrence of symptoms or irregular bleeding: antiepileptic medicines such as carbamazepine, phenytoin, phenobarbital and primidone barbiturates such as amobarbital rifamycin antibiotics such as rifabutin and rifampicin. Some women with diabetes may need small adjustments in their dose of insulin or antidiabetic tablets while taking this medicine. You should monitor your blood sugar and seek advice from your doctor or pharmacist if your blood sugar control seems to be altered after starting this medicine.